MicroRNA and drug resistance
نویسندگان
چکیده
منابع مشابه
MicroRNA-in drug resistance
Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. Over the last three decades, considerable progress has been made on the treatment of CRC. For example, it has been estimated that over 80% of patients diagnosed with CRC after 2010 received chemotherapy [1]. Despite considerable success however, resistance to chemotherapeutic treatment has emerged as an obstacle...
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عفونت و تهاجم ارگانیسم های انگلی به بدن، عامل اصلی بیماری و مرگ انسانها از آغاز بشریت بوده است . در حقیقت بسیاری از اشکال حیات بدون غلبه بر ارگانیسم های زنده دیگر، قادر به ادامه زندگی نخواهند بود. انسانها معمولا مستعد تهاجم ارگانیسم های کوچکتری مانند کرمها، آمیب ها، قارچها، باکتریها و ویروسها هستند. این عوامل مکان خاصی را در بدن انتخاب کرده، مواد ضروری لازم برای حیات و تکثیر خود را دریافت نموده...
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Introduction: Malaria is a public health problem for approximately 2.4 billion people, 40% of the world’s population, particularly in the tropical and subtropical countries. Countries in Asia, and Latin America, the islands of the South, West, and central pacific ocean are all affected. Drug resistance is the greatest challenge in combating against malaria. Drug resistance in malaria is now w...
متن کاملMicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia.
BACKGROUND MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic leukemia. DESIGN AND METHODS Expression levels of 397 microRNA (including novel microRNA) were measured by quantitative real-time polymerase chain...
متن کاملMicroRNA expression profiles of drug-resistance breast cancer cells and their exosomes
Exosomes have been shown to transmit drug resistance through delivering miRNAs. We aimed to explore their roles in breast cancer. Three resistant sublines were established by exposing parental MDA-MB-231 cell line to docetaxel, epirubicin and vinorelbine, respectively. Preneoadjuvant chemotherapy biopsies and paired surgically-resected specimens embedded in paraffin from 23 breast cancer patien...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2010
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2010.18